Investigation into the Effects of an Individual Amino Acid on Protein Function by Means of a Resonant Recognition Model
Identifieur interne : 000D34 ( Main/Exploration ); précédent : 000D33; suivant : 000D35Investigation into the Effects of an Individual Amino Acid on Protein Function by Means of a Resonant Recognition Model
Auteurs : Charalambos Chrysostomou [Royaume-Uni] ; Huseyin Seker [Royaume-Uni] ; Nizamettin Aydin [Turquie]Source :
- Lecture Notes in Computer Science [ 0302-9743 ]
Abstract
Abstract: Upon identification of a new protein it is important to single out these amino acids responsible for the structural classification of the protein as well as the amino acids contributing to the protein’s specific biological characterisation. A novel approach is presented to identify and quantify this cause and effect relationship between amino acid and protein. This exploits the Common Frequency Peak (CFP) that it extracts from the Resonant Recognition Model (RRM). Applicability and robustness of the method are shown on a case study where five different protein families of the influenza A virus Neuraminidase (NA) genes are studied. They include H1N1, H1N2, H2N2, H3N2 and H5N1. The analyses identified five segments, namely three between H1N1 and H5N1 and two between H1N2, H2N2 and H3N2 and suggested that they play a key role in Influenza A NA gene functionality and can potentially be considered as target areas for future antiviral drugs and vaccines such as neuraminidase inhibitors.
Url:
DOI: 10.1007/978-3-642-24082-9_28
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000002
- to stream Istex, to step Curation: 000002
- to stream Istex, to step Checkpoint: 000155
- to stream Main, to step Merge: 000D39
- to stream Main, to step Curation: 000D34
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Investigation into the Effects of an Individual Amino Acid on Protein Function by Means of a Resonant Recognition Model</title><author><name sortKey="Chrysostomou, Charalambos" sort="Chrysostomou, Charalambos" uniqKey="Chrysostomou C" first="Charalambos" last="Chrysostomou">Charalambos Chrysostomou</name></author><author><name sortKey="Seker, Huseyin" sort="Seker, Huseyin" uniqKey="Seker H" first="Huseyin" last="Seker">Huseyin Seker</name></author><author><name sortKey="Aydin, Nizamettin" sort="Aydin, Nizamettin" uniqKey="Aydin N" first="Nizamettin" last="Aydin">Nizamettin Aydin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E29194F2BBDFE0735935A417923C9F9BEB934519</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/978-3-642-24082-9_28</idno><idno type="url">https://api.istex.fr/ark:/67375/HCB-40D1KGQ2-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000002</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000002</idno><idno type="wicri:Area/Istex/Curation">000002</idno><idno type="wicri:Area/Istex/Checkpoint">000155</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000155</idno><idno type="wicri:doubleKey">0302-9743:2011:Chrysostomou C:investigation:into:the</idno><idno type="wicri:Area/Main/Merge">000D39</idno><idno type="wicri:Area/Main/Curation">000D34</idno><idno type="wicri:Area/Main/Exploration">000D34</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Investigation into the Effects of an Individual Amino Acid on Protein Function by Means of a Resonant Recognition Model</title><author><name sortKey="Chrysostomou, Charalambos" sort="Chrysostomou, Charalambos" uniqKey="Chrysostomou C" first="Charalambos" last="Chrysostomou">Charalambos Chrysostomou</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bio-Health Informatics Research Group, Centre for Computational Intelligence, Department of Informatics, Faculty of Technology, De Montfort University, LE1 9BH, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Seker, Huseyin" sort="Seker, Huseyin" uniqKey="Seker H" first="Huseyin" last="Seker">Huseyin Seker</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bio-Health Informatics Research Group, Centre for Computational Intelligence, Department of Informatics, Faculty of Technology, De Montfort University, LE1 9BH, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Aydin, Nizamettin" sort="Aydin, Nizamettin" uniqKey="Aydin N" first="Nizamettin" last="Aydin">Nizamettin Aydin</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Computer Engineering, Yildiz Technical University</wicri:regionArea><wicri:noRegion>Yildiz Technical University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Turquie</country></affiliation></author></analytic><monogr></monogr><series><title level="s" type="main" xml:lang="en">Lecture Notes in Computer Science</title><idno type="ISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="ISSN">0302-9743</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-9743</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Upon identification of a new protein it is important to single out these amino acids responsible for the structural classification of the protein as well as the amino acids contributing to the protein’s specific biological characterisation. A novel approach is presented to identify and quantify this cause and effect relationship between amino acid and protein. This exploits the Common Frequency Peak (CFP) that it extracts from the Resonant Recognition Model (RRM). Applicability and robustness of the method are shown on a case study where five different protein families of the influenza A virus Neuraminidase (NA) genes are studied. They include H1N1, H1N2, H2N2, H3N2 and H5N1. The analyses identified five segments, namely three between H1N1 and H5N1 and two between H1N2, H2N2 and H3N2 and suggested that they play a key role in Influenza A NA gene functionality and can potentially be considered as target areas for future antiviral drugs and vaccines such as neuraminidase inhibitors.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Turquie</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Chrysostomou, Charalambos" sort="Chrysostomou, Charalambos" uniqKey="Chrysostomou C" first="Charalambos" last="Chrysostomou">Charalambos Chrysostomou</name></noRegion><name sortKey="Chrysostomou, Charalambos" sort="Chrysostomou, Charalambos" uniqKey="Chrysostomou C" first="Charalambos" last="Chrysostomou">Charalambos Chrysostomou</name><name sortKey="Seker, Huseyin" sort="Seker, Huseyin" uniqKey="Seker H" first="Huseyin" last="Seker">Huseyin Seker</name><name sortKey="Seker, Huseyin" sort="Seker, Huseyin" uniqKey="Seker H" first="Huseyin" last="Seker">Huseyin Seker</name></country><country name="Turquie"><noRegion><name sortKey="Aydin, Nizamettin" sort="Aydin, Nizamettin" uniqKey="Aydin N" first="Nizamettin" last="Aydin">Nizamettin Aydin</name></noRegion><name sortKey="Aydin, Nizamettin" sort="Aydin, Nizamettin" uniqKey="Aydin N" first="Nizamettin" last="Aydin">Nizamettin Aydin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D34 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D34 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E29194F2BBDFE0735935A417923C9F9BEB934519
|texte= Investigation into the Effects of an Individual Amino Acid on Protein Function by Means of a Resonant Recognition Model
}}
| This area was generated with Dilib version V0.6.33. |  |